Astaxanthin, Compared to Other Carotenoids, Increases the Efficacy of Methotrexate in Rat Adjuvant Arthritis (2024)

Table of Contents
Abstract List of references

Astaxanthin, Compared to Other Carotenoids, Increases the Efficacy of Methotrexate in Rat Adjuvant Arthritis (1) https://doi.org/10.3390/ijms25168710 · Astaxanthin, Compared to Other Carotenoids, Increases the Efficacy of Methotrexate in Rat Adjuvant Arthritis (2)

Journal: International Journal of Molecular Sciences, 2024, №16, p.8710

Publisher: MDPI AG

Authors:

  1. Katarína Pružinská
  2. Martin Chrastina
  3. Sasan Khademnematolahi
  4. Veronika Vyletelová
  5. Lívia Gajdošová
  6. Lucia Pastvová
  7. František Dráfi
  8. Silvester Poništ
  9. Ľudmila Pašková
  10. Jarmila Kucharská
  11. Zuzana Sumbalová
  12. Jana Muchová
  13. Silvia Martiniaková
  14. Katarína Bauerová

Abstract

This in vivo study performed in rat adjuvant arthritis aims to advance the understanding of astaxanthin’s therapeutic properties for the possible treatment of rheumatoid arthritis (RA) in monotherapy and along with the standard RA treatment, methotrexate (MTX), in combination therapy. The main goal was to elucidate astaxanthin’s full therapeutic potential, evaluate its dose dependency, and compare its effects in monotherapy with other carotenoids such as β-carotene and β-cryptoxanthin (KXAN). Moreover, potential differences in therapeutic activity caused by using different sources of astaxanthin, synthetic (ASYN) versus isolated from Blakeslea trispora (ASTAP), were evaluated using one-way ANOVA (Tukey-Kramer post hoc test). KXAN was the most effective in reducing plasma MMP-9 levels in monotherapy, significantly better than MTX, and in reducing hind paw swelling. The differences in the action of ASTAP and ASYN have been observed across various biometric, anti-inflammatory, and antioxidative parameters. In combined therapy with MTX, the ASYN + MTX combination proved to be better. These findings, especially the significant anti-arthritic effect of KXAN and ASYN + MTX, could be the basis for further preclinical studies.

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Astaxanthin, Compared to Other Carotenoids, Increases the Efficacy of Methotrexate in Rat Adjuvant Arthritis (2024)
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